Complete Liquid-Liquid Extraction

  • Duration: 3.25 hours for on-demand
  • Experience level: Intermediate
  • Delivery methods: Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
  • Type of course: Universal
  • Applicable to manufacturer(s): Agilent | Bruker | CTC analytics | GERSTEL | GL Sciences | Leco | PerkinElmer | Sciex | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
  • CPD Approved: Approved
  • Scheduled course price: £195.00 + TAX per delegate
  • Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
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Complete Liquid-Liquid Extraction
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Your complete guide to Liquid-Liquid Extraction

Module 1 of the Complete Sample Preparation course.

This Complete Liquid-Liquid Extraction (LLE) training is approved by the Royal Society of Chemistry (RSC) for purposes of Continuing Professional Development (CPD). Take an in-depth theoretical approach to LLE, covering the principles of solvent extraction, partitioning, extraction efficiency, solvent selection, method optimisation, and troubleshooting. You will gain a practical understanding of one of the most widely used sample preparation techniques in analytical chemistry. Enhance your knowledge further by applying what’s learnt on this course to case studies involving LLE.

This course can be combined with additional modules from the Complete Sample Preparation course to create a learning pathway tailored to your analytical applications and experience level.

Why should I join?

On completion of this course, you will have an overview of LLE and its application in analytical laboratories and industrial processes.

 

This LLE training gives you:

  • A clear understanding of the principles behind LLE and solvent partitioning
  • Explanations of how analytes distribute between immiscible liquid phases
  • An understanding of extraction efficiency and key method optimisation parameters
  • Insight into solvent selection and matrix modification techniques including pH adjustment, salting out, and derivatisation
  • A practical introduction to common LLE equipment, automation options, and troubleshooting approaches
  • A strong foundation for progressing to more sample preparation and analytical method development topics
  • A valuable refresher if you have not used LLE techniques recently
Combine other days or modules.

What would I learn?

This course focuses on providing a complete understanding of LLE. You will learn:

  • The principles of solvent extraction and the stages involved in the process.
  • How analytes partition between aqueous and organic phases
  • What distribution coefficients are and how they influence extraction performance.
  • The differences between extraction, washing, back extraction, and back washing.
  • How solvent choice impacts recovery, selectivity, and analytical performance.
  • The influence of pH, salts, temperature, and derivatisation on extraction efficiency.
  • Practical considerations including phase separation, drying extracts, concentration, and handling emulsions
  • Real-world applications through LLE case studies

What knowledge will I gain?

By the end of the course, you will:

  • Be able to confidently define LLE and explain the principles behind solvent partitioning
  • Understand how solutes transfer between two immiscible liquid phases to reach equilibrium
  • Know how distribution coefficients (KD) influence extraction recovery and method effectiveness
  • Understand the importance of solvent selection, polarity, miscibility, and extraction conditions
  • Recognise the key factors affecting extraction efficiency, including solvent volume, extraction time, temperature, and matrix modifications
  • Learn how pH adjustment and salting-out techniques can be used to improve analyte recovery
  • Become familiar with modern and miniaturised extraction techniques used to improve efficiency and reduce solvent consumption
  • Understand common sources of extraction problems, including emulsion formation, solvent selection challenges, particulate interference, and volatile losses
  • Gain an appreciation of how LLE is used in environmental, industrial, pharmaceutical, and analytical testing applications

Is this course for me?

This RSC-approved, for purposes of CPD, training is designed for anyone who would like an understanding of LLE and sample preparation techniques.

  • Laboratory analysts and technicians performing sample preparation and extraction procedures
  • Scientists developing analytical methods involving GC, GC-MS, LC, or LC-MS
  • Laboratory managers overseeing analytical workflows and sample preparation activities.
  • Data analysts and report writers seeking a better understanding of sample preparation influences on analytical results
  • Service engineers supporting sample preparation and analytical laboratory equipment.
  • Sales, commercial, and marketing teams working with sample preparation products, automation systems, chemicals, or analytical instrumentation
  • Researchers and scientists wanting a stronger understanding of extraction science and laboratory best practice

If LLE is part of your laboratory, research, environmental, industrial, or product development work, this introductory course delivered by subject matter experts will provide a solid understanding in this analytical sample preparation technique.

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