Introduction to advanced GC and GC-MS techniques

  • Duration: 2 hours for on-demand
  • Experience level: Intermediate
  • Delivery methods: Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
  • Type of course: Universal
  • Applicable to manufacturer(s): Agilent | Bruker | CDS Analytical | CTC analytics | Frontier | GERSTEL | GL Sciences | Leco | Markes International | OI Analytical | PerkinElmer | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
  • CPD Approved: Approved
  • Scheduled course price: £130.00 + TAX per delegate
  • Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
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Introduction to advanced GC and GC-MS techniques
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Your applied guide to advanced separation, identification, and data analysis techniques in gas chromatography (GC) and GC-mass spectrometry (GC-MS)

Module 10 of the Complete GC and GC-MS and module 2 of The GC and GC-MS Clinic course

Introduction to advanced GC and GC-MS techniques module is approved by the Royal Society of Chemistry (RSC) for the purposes of Continuing Professional Development (CPD). Designed for professionals, students and chemists looking to explore a range of advanced techniques used in modern GC and GC-MS laboratories, including mass spectral interpretation (MSI), selective discrimination, fast GC, deconvolution, multidimensional GC, and chemometrics. The course provides insight into solving complex analytical challenges, improving selectivity and resolution and extracting information from datasets.

This module can be combined with any of the other twelve modules in the Complete GC and GC-MS to tailor your training needs.

Why should I join?

On completion of this module 10 training,  you will gain an understanding of advanced analytical tools that can be applied when conventional methods are no longer sufficient, giving you:

  • An overview of advanced GC and GC-MS techniques used for analytical applications
  • Understanding of the principles of mass spectral interpretation and structural elucidation
  • Insight into selective discrimination techniques for improving sensitivity and reducing matrix interferences
  • Understanding of fast GC strategies for increasing sample throughput while maintaining analytical quality
  • Practical guidance on resolving co-elutions using deconvolution and multidimensional separations
  • An introduction to heart-cutting GC, two-dimensional GC (GC×GC), and advanced modulation approaches
  • Understanding of chemometric tools used to identify patterns, trends, outliers, and relationships within analytical datasets
Combine other days or modules.

What would I learn?

This module focuses on the advanced techniques that can be used to improve analytical performance, identification confidence, and data interpretation, you will learn:

  • The fundamentals of mass spectral interpretation and how fragmentation patterns can be used to identify molecular structures
  • How isotopic abundances and isotope patterns can assist with elemental composition determination and compound identification
  • The principles and applications of selective discrimination using inlet temperature, pressure, and volatility differences
  • How selective transfer can be used to improve detection limits, remove unwanted matrix components, and protect columns and detectors
  • The implementation of fast GC including column selection, carrier gas optimisation, and temperature programming strategies
  • The principles of deconvolution and how it can be used to separate overlapping mass spectra and co-eluting compounds
  • How multidimensional GC techniques such as heart-cutting GC and GC×GC increase separation power and analytical capability

What knowledge will I gain?

By the end of the module, you will:

  • Understand how advanced GC and GC-MS techniques can be used to solve complex analytical challenges
  • Be able to interpret mass spectra using fragmentation patterns, isotopic abundances, and molecular ion information
  • Understand how selective discrimination can be used to improve sensitivity, reduce matrix effects, and extend instrument lifetime
  • Learn how to significantly reduce analysis times through fast GC without compromising analytical performance
  • Know strengths and limitations of deconvolution software and its role in identifying co-eluting compounds
  • Be able to evaluate whether multidimensional GC approaches are appropriate for a particular sample or analytical problem
  • Understand how GC×GC provides additional separation based on multiple physicochemical properties such as volatility and polarity
  • How chemometric tools can uncover trends, classify samples, detect outliers, and predict sample characteristics from complex datasets

Is this course for me?

This course is designed for anyone who would like an introduction to advanced GC and GC-MS techniques

  • Laboratory analysts & technicians using GC and GC-MS
  • Laboratory or line managers overseeing GC and GC-MS instruments and analysis
  • Data analysts and report writers who work with GC and GC-MS
  • Service engineers who want chemistry focused introduction to GC and GC-MS
  • Sales, commercial or marketing teams who work with GC and GC-MS components, instruments, or services in anyway and would like more in-depth knowledge

If GC and GC-MS touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.

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