The LC and LC-MS Clinic
- Duration: 2 days for live courses 14.50 hours for on-demand
- Experience level: Intermediate
- Delivery methods: Face-to-face | Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | CTC analytics | JASCO | PerkinElmer | Sciex | Scion | Shimadzu | Thermo | Waters |
- CPD Approved: Approved
- Scheduled course price: £825.00 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your advanced troubleshooting, optimisation and problem-solving training for experienced liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) users
Day 4 and 5 of the Complete LC and LC-MS.
The LC & LC-MS Clinic is approved by the Royal Society of Chemistry (RSC) for the purposes of Continuing Professional Development (CPD) and is designed for professionals, students and chemists who are looking to develop advanced knowledge of LC and LC-MS. This course focuses on challenges encountered during method development, advanced analysis, maintenance and troubleshooting of LC and LC-MS systems. Participants will gain the knowledge required to optimise method performance, apply advanced analytical techniques, maintain instruments correctly and systematically diagnose complex problems. Based on LC and LC-MS method development, advanced techniques, maintenance and troubleshooting, this course provides a comprehensive understanding of how to maximise analytical performance and data quality throughout the entire workflow.
Whether you are developing new methods, improving existing methods, working with complex sample matrices, investigating chromatographic problems, maintaining analytical systems, or applying advanced LC-MS techniques, this course provides the practical knowledge and problem-solving skills needed to achieve better analytical outcomes.
Why should I join?
This course provides a structured approach to method development, advanced analytical techniques, maintenance and troubleshooting whilst improving method performance and instrument reliability, giving you:
- A systematic approach to developing, optimising, and troubleshooting LC and LC-MS methods
- Advanced understanding of chromatographic and mass spectrometric performance improvement strategies
- Insight into the causes of poor sensitivity, selectivity, resolution, reproducibility, and instrument performance
- Knowledge of advanced LC and LC-MS techniques used to solve challenging analytical problems
- Practical guidance on maintaining LC and LC-MS systems to maximise uptime and reliability
- A valuable opportunity to develop higher-level troubleshooting, optimisation, and decision-making skills
What would I learn?
This course focuses on advanced troubleshooting, optimisation, maintenance, and analytical problem solving, you will learn:
- How to systematically develop and optimise LC and LC-MS methods for a wide range of analytical applications
- How sampling, sample preparation, injection, separation, detection, and data processing influence analytical results
- Advanced strategies for improving chromatographic resolution, sensitivity, selectivity, and throughput
- The principles of advanced chromatographic techniques including HILIC, ion-pair chromatography, ion chromatography, multidimensional chromatography, and LC×LC
- How to interpret LC-MS data using fragmentation patterns, isotopic information, and accurate mass measurements
- How to implement effective preventative maintenance programmes for LC and LC-MS systems
- How to clean, maintain and optimise columns, detectors, pumps, autosamplers, vacuum systems, and ion sources
- How to systematically investigate, diagnose and resolve chromatographic and mass spectrometric problems
- How to evaluate method performance, validation requirements, and quality assurance procedures
What knowledge will I gain?
By the end of the course, you will:
- Understand how to take a structured approach to LC and LC-MS method development, optimisation, and troubleshooting
- Be able to identify the most significant factors influencing chromatographic and mass spectrometric performance
- Understand how advanced analytical techniques can improve identification confidence, sensitivity, and selectivity
- Understand the maintenance requirements of major LC and LC-MS instrument components and their impact on data quality
- Be able to identify root causes of chromatographic and mass spectrometric problems more efficiently
- Understand how contamination, carryover, instrument condition, and operating parameters affect analytical performance
- Understand how to critically evaluate existing methods and identify opportunities for improvement
- Develop the expertise required to maximise instrument performance, reliability, and analytical results
Is this course for me?
This training is designed for anyone who would like advanced knowledge of both techniques.
- Laboratory analysts and technicians using LC, HPLC, and LC-MS systems
- Laboratory or line managers overseeing LC and LC-MS instruments, methods, and analytical performance
- Data analysts and report writers who work with LC and LC-MS data and interpretation
- Scientists involved in method development, optimisation, troubleshooting, and system maintenance
- Service engineers seeking a chemistry-focused understanding of LC and LC-MS instrumentation and applications
- Sales, commercial and marketing teams who work with LC and LC-MS instruments, consumables, components, or analytical services and would like more in-depth knowledge
If LC and LC-MS touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.
Feedback from previous attendees
“The fact that it covered a lot of topics and allowed to review and learn a little bit of everything that involves the use of these type of techniques and equipments.” July 2021.
“Brilliant, very informative.” Mollie Nero, Project Scientist, Broughton Nicotine Services (February 2021).
“Section on troubleshooting and method development was very good, instructor was very knowledgeable. Content was clear and easy to follow.” November 2020.
“Professional, high quality delivery, keep track on time. My previous experience with HPLC courses is not as great as to time and quality.” (May 2019).
