Hands-on LC-MS maintenance
- Duration: 1 day for live courses
- Experience level: Intermediate
- Delivery methods: Face-to-face | Offsite training & consultancy | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | JASCO | PerkinElmer | Sciex | Scion | Shimadzu | Thermo | Waters |
- CPD Approved: Approved
- Scheduled course price: £650.00 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your hands-on approach to learning liquid chromatography-mass spectrometry (LC-MS) maintenance
Day 4 of our Hands-on HPLC and LC-MS
Combine the practical theory of LC-MS maintenance with laboratory-based exercises in this Royal Society of Chemistry (RSC) approved training for the purposes of Continued Professional Development (CPD). This course is designed to bridge the gap between theory and practice, enabling you to confidently maintain LC-MS instrumentation within the laboratory.
This Hands-on course is ideal for students, analysts and professionals who want to gain practical experience with all aspects of LC-MS maintenance including vacuum systems, ion sources, electrospray probes, ion optics, calibration, tuning, and preventative maintenance procedures. Learn how to identify common performance issues while developing the practical skills needed to maximise instrument uptime, sensitivity, and reliability.
Why should I join?
On completion, you will have both the theoretical knowledge and practical experience required to confidently maintain LC-MS systems in your laboratory.
This Hands-on LC-MS maintenance course gives you:
- Strong practical skills for maintaining LC-MS instrumentation
- Practical guidance on vacuum systems, ion sources, and electrospray probes
- Hands-on experience performing calibration and tuning procedures
- A structured approach to preventative maintenance planning
- Practical techniques for identifying leaks, contamination, and sensitivity loss
- Experience maintaining ion optics and vacuum components
- Confidence interpreting maintenance-related performance issues and instrument diagnostics
What would I learn?
A user-friendly LC-MS maintenance course that combines in-depth theory with practical laboratory exercises, you will learn:
- The principles of preventative maintenance for LC-MS systems
- How to maintain LC fluidic systems, mobile phases, pumps, and autosamplers
- How to perform leak checks, mass calibration, and instrument tuning
- The operation and maintenance requirements of roughing pumps, turbo pumps, and vacuum systems
- How to safely vent and pump down an LC-MS system
- Routine maintenance procedures for ion sources, electrospray probes, and sample cones
- How to inspect, clean and maintain ion blocks and transfer ion optics
- The maintenance requirements of detectors, electron multipliers, and associated components
- Approaches to contamination, charging effects, sensitivity loss, and poor instrument performance
What knowledge will I gain?
- Understand the critical role of preventative maintenance in ensuring reliable LC-MS performance
- Understand how contamination, leaks and poor vacuum impact sensitivity, mass accuracy, and analytical reliability
- Explain the maintenance requirements of ion sources, electrospray probes, ion optics, detectors, and vacuum components
- Understand how calibration and tuning verify instrument performance and analytical readiness
- Recognise symptoms of contamination and developing faults before they affect analytical results
- Understand correct procedures for venting, servicing, and returning LC-MS systems to operation
- Diagnose common causes of poor sensitivity, instability, charging effects, and calibration failures
- Create practical preventative maintenance schedules tailored to laboratory workloads and applications
Is this course for me?
This RSC approved for purposes of CPD training is designed for anyone responsible for maintaining, operating, or supporting LC-MS systems, including:
- Analysts & technicians requiring training or a clear structured refresher of HPLC and LC-MS
- Laboratory or line managers overseeing HPLC and LC-MS instrumentation
- Data analysts and report writers who interpret results but do not use the instruments
- Service and consultant engineers who need both a theoretical and hands-on reminder
- Sales, marketing, or commercial teams working with HPLC and LC-MS systems, consumables, data, or laboratory services
If HPLC and LC-MS touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.
Course combinations
Can’t attend the full course? No worries, combine days or modules to create training that works best for you. The more days you book the larger the discount.
- For 2 days, pay £1250
- For 3 days, pay £1825
- For 4 days, pay £2350
- For 5 days, pay £2850
Please note, discounts won’t apply when booking but will appear on your invoice.
