Applied GC and GC-MS method development
- Duration: 4.50 hours for on-demand
- Experience level: Intermediate
- Delivery methods: Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | CDS Analytical | CTC analytics | Frontier | GERSTEL | GL Sciences | Leco | OI Analytical | PerkinElmer | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
- CPD Approved: Approved
- Scheduled course price: £292.50 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your applied guide to developing gas chromatography (GC) and GC- mass spectrometry (GC-MS) methods
Module 9 of the Complete GC and GC-MS and module 1 of The GC and GC-MS Clinic course
Applied GC and GC-MS method development module is approved by the Royal Society of Chemistry (RSC) for the purposes of Continuing Professional Development (CPD). Designed for professionals, students and chemists, providing an in-depth exploration of GC and GC-MS method development, covering the entire analytical workflow from defining objectives and selecting techniques, through to optimisation, validation and quality assurance. You will learn how to systematically develop dependable, sensitive and robust analytical methods that are fit for purpose and capable of delivering high-quality data.
This module can be combined with any of the other twelve modules in the Complete GC and GC-MS to tailor your training needs.
Why should I join?
On completion of this module 9 training, you will be able to develop a structured approach to designing, optimising, and validating GC and GC-MS methods, giving you:
- An overview of the GC and GC-MS method development process
- Understanding of how analytical objectives determine method design and instrument selection
- Insight into optimisation strategies for sampling, sample preparation, injection, separation, detection, and data acquisition
- Practical guidance on troubleshooting common chromatographic and mass spectrometric challenges
- A detailed understanding of method performance requirements, including accuracy, precision, linearity, and detection limits
- A valuable refresher for analysts looking to optimise existing methods or develop new analytical solutions
What would I learn?
This module focuses on the aspects of designing and developing effective chromatographic methods, you will learn:
- How to define analytical objectives and determine the most appropriate analytical approach
- How to plan and structure a logical method development workflow
- The importance of sampling, storage, transportation, and sample preparation in method performance
- How to select and optimise sampling techniques for GC and GC-MS
- Learn to optimise injection techniques including split, splitless, on-column, and large-volume injection
- How carrier gas selection, flow rates, and inlet conditions influence chromatographic performance
- The principles of column selection, including stationary phase chemistry, film thickness, internal diameter, and column length
- The fundamentals of GC-MS optimisation including ionisation techniques and mass analysers
What knowledge will I gain?
By the end of the module, you will:
- Understand the complete process of developing a GC or GC-MS method from start to finish
- Be able to identify the most critical parameters affecting method performance
- Understand how to systematically optimise chromatographic and mass spectrometric conditions
- Know how to maximise sensitivity while minimising analyte loss and contamination
- Understand how to work with difficult analytes including thermally labile, active, trace-level, and high molecular weight compounds
- Be able to assess method limitations and establish suitable operating ranges
- Understand calibration strategies and the determination of limits of detection, quantitation, and reporting
- Know how to evaluate method performance through measurements of accuracy, precision, repeatability and precision
- Gain insight into quality assurance, including blanks, spikes, internal standards, surrogate standards, and system suitability
- Understand the principles of method validation and analytical accreditation requirements
Is this course for me?
This course is designed for anyone who would like to learn method development for both techniques.
- Laboratory analysts & technicians using GC and GC-MS
- Laboratory or line managers overseeing GC and GC-MS instruments and analysis
- Data analysts and report writers who work with GC and GC-MS
- Service engineers who want chemistry focused introduction to GC and GC-MS
- Sales, commercial or marketing teams who work with GC and GC-MS components, instruments, or services in anyway and would like more in-depth knowledge
If GC and GC-MS touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.
