Applied LC and LC-MS troubleshooting
- Duration: 3.50 hours for on-demand
- Experience level: Intermediate
- Delivery methods: Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | CTC analytics | JASCO | PerkinElmer | Sciex | Scion | Shimadzu | Thermo | Waters |
- CPD Approved: Approved
- Scheduled course price: £227.50 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your applied guide to liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) troubleshooting
Module 12 of the Complete LC and LC-MS course and module 4 of The LC and LC-MS Clinic course.
Applied LC and LC-MS troubleshooting is approved by the Royal Society of Chemistry (RSC) for the purposes of Continuing Professional Development (CPD). Designed for professionals, students and analytical scientists, this module explores the practical approaches required to diagnose and solve problems encountered in LC and LC-MS systems. As well as covering logical troubleshooting strategies, chromatographic problem solving, system diagnostics and mass spectrometry fault finding to help you rapidly identify and resolve laboratory issues.
This module can be combined with any of the other twelve modules in the Complete LC and LC-MS to tailor your training needs.
Why should I join?
On completion of this module 12 training, you will gain an understanding of troubleshooting strategies used throughout LC and LC-MS, giving you:
- An overview of structured troubleshooting approaches for LC and LC-MS systems
- Understanding of how to diagnose chromatographic, instrument and mass spectrometry problems
- Insight into identifying root causes rather than treating symptoms
- Practical guidance on resolving common LC system faults and chromatographic issues
- Knowledge of troubleshooting procedures for LC-MS vacuum systems and ionisation sources
- Understanding of how preventative measures can reduce instrument downtime and recurring problems
What would I learn?
This module focuses on troubleshooting LC and LC-MS instrumentation and applications, you will learn:
- How to apply a logical and systematic troubleshooting workflow to analytical problems
- How to identify and isolate faults in samples, methods, and instrument settings
- How to diagnose problems associated with pumps, autosamplers, columns, and detectors
- The causes of common chromatographic issues including ghost peaks, peak tailing, peak fronting, and split peaks
- How to investigate baseline drift, noise, contamination, and sensitivity problems
- How to troubleshoot LC-MS vacuum systems, gas supplies, and electrospray ionisation sources
- The principles of diagnosing mass spectrometry performance issues including contamination and charging effects
What knowledge will I gain?
By the end of the module, you will:
- Understand how to approach troubleshooting using a structured and repeatable process
- Know how to identify the most common causes of chromatographic and mass spectrometric problems
- Understand how samples, solvents and mobile phases contribute to analytical issues
- Know how to diagnose retention time shifts, sensitivity losses, and changes in selectivity
- Understand the causes of baseline noise, contamination, and carryover problems
- Know how to isolate faults within LC and LC-MS systems efficiently
- Gain confidence in resolving analytical problems and preventing their reoccurrence
Is this course for me?
This course is designed for anyone who would like to improve their ability to troubleshoot LC and LC-MS problems.
- Laboratory analysts and technicians responsible for operating LC and LC-MS systems
- Laboratory managers responsible for analytical performance and instrument uptime
- Scientists involved in troubleshooting, method support, and system optimisation
- Service engineers seeking a deeper understanding of LC and LC-MS fault diagnosis
- Sales, commercial and marketing teams supporting chromatography and mass spectrometry products and services
If LC and LC-MS touches your work in any way, this practical course delivered by experts in the field will equip you with the knowledge required to understand troubleshooting for these techniques.
Select the courses you are interested in:
Feedback from previous attendees
“Useful for day to day instrument problems.” Mollie Nero, Project Scientist, Broughton Nicotine Services (February 2021).
