Complete Derivatisation
- Duration: 3.25 hours for on-demand
- Experience level: Intermediate
- Delivery methods: Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | CTC analytics | GERSTEL | GL Sciences | Leco | PerkinElmer | Sciex | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
- CPD Approved: Approved
- Scheduled course price: £195.00 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your complete guide to Derivatisation
Module 2 of the Complete Sample Preparation course.
This Complete Derivatisation training is approved by the Royal Society of Chemistry (RSC) for purposes of Continuing Professional Development (CPD). Take an in-depth approach to derivatisation, covering the principles of chemical modification, functional group chemistry, reaction mechanisms, reagent selection, method development, optimisation, instrumentation, case studies, and troubleshooting. Gain an understanding of how derivatisation is used to improve analytical performance across GC, GC-MS, LC, LC-MS, and other analytical techniques. The course combines theoretical knowledge with case study applications to help develop robust and effective derivatisation strategies.
This course can be combined with additional modules from the Complete Sample Preparation course to create a learning pathway tailored to your analytical applications and experience level.
Why should I join?
On completion of this training, you will have a comprehensive understanding of derivatisation and its application in modern analytical laboratories.
This derivatisation course gives you:
- A clear understanding of the principles behind derivatisation and why chemical modification is used in analytical chemistry
- How derivatisation can improve analyte suitability, chromatographic efficiency, and detector response
- Insight into functional groups commonly targeted during derivatisation
- An understanding of reagent selection and the requirements for successful derivatisation reactions
- Practical guidance on method design, optimisation, reagent handling, and reaction parameters
- An introduction to offline, online, pre-column, post-column, in-liner, headspace, and SPME derivatisation techniques
- Real-world examples demonstrating how derivatisation can solve analytical challenges
- A strong foundation for progressing to advanced analytical method development and optimisation activities
What would I learn?
This course focuses on providing a complete understanding of derivatisation. You will learn:
- The principles of derivatisation and the reasons for applying chemical modification in analytical chemistry
- How derivatisation changes chemical and physical properties including reactivity, volatility, solubility, and detectability
- Why derivatisation is used in GC, GC-MS, LC, and LC-MS applications
- The role of polarity, intermolecular interactions, and functional groups in analytical performance
- How to select suitable derivatisation reagents for different analytes and detector systems
- Method development considerations including reagent selection, reaction solvents, temperature, time, and catalyst optimisation
- The theory and application of derivatisation approaches
- Automated derivatisation approaches using robotic systems and online instrumentation
- Practical applications through a range of GC, GC-MS, LC, and LC-MS case studies.
- Common sources of error and effective troubleshooting strategies.
What knowledge will I gain?
By the end of the course, you will:
- Be able to confidently define derivatisation and explain its role in analytical chemistry
- Understand how derivatisation improves analyte suitability for chromatographic and spectrometric analysis
- Recognise how functional groups influence analyte behaviour and determine derivatisation requirements
- Understand the relationship between analyte polarity, intermolecular interactions, volatility, and chromatographic performance
- Know how to select appropriate derivatisation reagents for different analytes, reaction pathways, and detector technologies
- Understand the practical requirements for robust derivatisation method development and optimisation
- Become familiar with common derivatisation chemistries including acylation, silylation, alkylation, and fluorescent derivatisation techniques
- Understand the benefits and limitations of automated, online, offline, pre-column, and post-column derivatisation approaches
- Learn how derivatisation can improve sensitivity, selectivity, chromatographic performance, and detector response
- Understand common derivatisation problems including incomplete reactions, reagent deterioration, low yield, hydrolysis, artefact formation, and contamination
- Gain an appreciation of how derivatisation is applied across environmental, pharmaceutical, industrial, forensic, food, and research laboratories
Is this course for me?
This RSC-approved, for purposes of CPD, training is designed for anyone who would like a complete understanding of derivatisation.
- Laboratory analysts and technicians performing sample preparation and derivatisation procedures.
- Scientists developing analytical methods involving GC, GC-MS, LC, and LC-MS.
- Laboratory managers overseeing analytical workflows and sample preparation activities
- Data analysts and report writers seeking a better understanding of how sample preparation influences analytical results.
- Service engineers supporting chromatographic and mass spectrometric instrumentation
- Sales, commercial, and marketing teams working with analytical instrumentation, sample preparation products, reagents, and automation systems
- Researchers and scientists wanting a stronger understanding of derivatisation chemistry and analytical best practice
If derivatisation is part of your laboratory, research, environmental, industrial, or product development work, this introductory course delivered by subject matter experts will provide a solid understanding in this analytical sample preparation technique.
