Practical Essentials of mass spectrometers for GC

  • Duration: 3 hours for on-demand
  • Experience level: Intermediate
  • Delivery methods: Offsite training & consultancy | On-Demand | Online | Onsite training & consultancy | Tailored training |
  • Type of course: Universal
  • Applicable to manufacturer(s): Agilent | Bruker | CDS Analytical | CTC analytics | Frontier | GERSTEL | GL Sciences | Leco | OI Analytical | PerkinElmer | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
  • CPD Approved: Approved
  • Scheduled course price: £195.00 + TAX per delegate
  • Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
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Practical Essentials of mass spectrometers for GC
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Your essential guide to mass spectrometers in gas chromatography (GC)

Module 6 of the Complete GC and GC-MS and the Practical Essentials of GC and GC-MS course

Practical Essentials of mass spectrometers for GC module is approved by the Royal Society of Chemistry (RSC) for the purposes of Continuing Professional Development (CPD). This module provides an in-depth exploration of mass spectrometers used with GC, covering the principles of ionisation, mass analysis, ion detection, and the practical applications of GC-MS for both qualitative and quantitative analysis. Designed for professionals, students and chemists, gain an understanding of how GC-MS systems operate, different ionisation methods work and how mass analysers influence analytical performance.

This module can be combined with any of the other twelve modules in the Complete GC and GC-MS to tailor your training needs.

Why should I join?

On completion of this module 6 training, you will develop an understanding of how mass spectrometers function within a GC-MS system, giving you:

  • An overview of GC-MS instrumentation and the role of mass spectrometry in analytical chemistry
  • Understanding of how analytes are ionised, fragmented, separated, and detected within a mass spectrometer
  • Insight into common ionisation techniques including electron ionisation (EI), positive chemical ionisation (PCI), negative chemical ionisation (NCI), photoionisation (PI), and field ionisation (FI)
  • An introduction to advanced techniques including SIM, SRM, MRM, high-resolution mass spectrometry, and tandem GC-MS
  • A valuable refresher for if you have not worked with GC and GC-MS for a while
Combine other days or modules.

What would I learn?

This module focuses on explaining how mass spectrometry works when coupled to GC and how GC-MS can be used to separate, identify, and quantify compounds, you will learn:

  • How gas chromatography and mass spectrometry work together to provide both separation and identification
  • How mass spectra are generated and how they are used as molecular fingerprints for compound identification
  • The principles of extracted ion chromatograms (EIC/XIC) and total ion chromatograms (TIC) and how they support targeted and non-targeted analyses
  • How molecular ion formation and fragmentation occur during ionisation
  • Differences between hard and soft ionisation techniques, and when each approach is appropriate
  • The operation of quadrupole, ion trap, Time of Flight (ToF), Orbitrap™, magnetic sector, and tandem mass spectrometers
  • How scan and SIM modes affect sensitivity, selectivity, and quantitative performance

What knowledge will I gain?

By the end of the module, you will:

  • Understand the key components of a GC-MS system, including ion sources, mass analysers, detectors, vacuum systems, and transfer lines
  • Be able to explain how ionisation techniques influence fragmentation patterns and analytical information
  • Understand mass resolution, mass accuracy, resolving power, and their impact on compound identification
  • Know how to select the most appropriate ionisation method and mass analyser for specific applications
  • Be familiar with high-resolution mass spectrometry and its application in molecular formula determination and complex sample analysis
  • Understand how SIM, scan, SRM, and MRM acquisition modes affect sensitivity and selectivity
  • Gain insight into spectral deconvolution and the identification of co-eluting compounds

Is this course for me?

This course is designed for anyone who would like to learn about mass spectrometers used in GC analysis.

  • Laboratory analysts & technicians using GC and GC-MS
  • Laboratory or line managers overseeing GC and GC-MS instruments and analysis
  • Data analysts and report writers who work with GC and GC-MS
  • Service engineers who want chemistry focused introduction to GC and GC-MS
  • Sales, commercial or marketing teams who work with GC and GC-MS components, instruments, or services in anyway and would like more in-depth knowledge

If GC and GC-MS touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.

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