Hands-on Liquid-Liquid Extraction
- Duration: 1 day for live courses
- Experience level: Advanced
- Delivery methods: Face-to-face | Offsite training & consultancy | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | CTC analytics | GERSTEL | GL Sciences | Leco | PerkinElmer | Sciex | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
- CPD Approved: Approved
- Scheduled course price: £650.00 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your Hands-on approach to learning liquid-liquid extraction
Module 3 of the Hands-on of Sample Preparation course.
Combine the practical theory of extraction (LLE) with laboratory-based exercises when attending this Hands-on training approved by the Royal Society of Chemistry (RSC) for purposes of Continued Professional Development (CPD). Apply the knowledge learned in each module with exercises involving solvent extraction, method development, optimisation, automation, and troubleshooting. Gain first-hand experience of the equipment, solvents, extraction workflows, and analytical considerations associated with one of the most widely used sample preparation techniques in analytical chemistry.
This Hands-on LLE course is designed for analysts, scientists, technicians, and laboratory professionals who would like to develop both a practical and theoretical understanding of solvent extraction techniques. The course combines extraction theory, sample preparation, solvent selection, optimisation, troubleshooting, and real-world applications with laboratory-based exercises that reinforces learning and builds confidence.
Why should I join?
On completion of this Hands-on LLE training, you will have both a strong theoretical understanding and practical experience of developing, performing, optimising, and troubleshooting LLE methods.
This Hands-on LLE course gives you:
- A clear understanding of the principles behind LLE and solvent partitioning
- Practical experience of designing and performing extraction procedures
- Knowledge of distribution coefficients and their influence on extraction efficiency and recovery
- Insight into solvent selection and analyte-solvent interactions
- Practical guidance on method optimisation using pH adjustment, salting-out, derivatisation, and extraction conditions
- Hands-on experience with manual and automated extraction workflows
- Exposure to modern extraction approaches including microextraction and QuEChERS methodologies
- Practical troubleshooting techniques for solving common extraction problems
This is your opportunity to develop both the knowledge and practical skills required to confidently apply LLE in the laboratory.
Combine other days or modules.
What would I learn?
This course focuses on providing an in-depth understanding of Liquid-Liquid Extraction combined with practical hands-on experience. You will learn:
- The principles of LLE and solvent partitioning
- How analytes distribute between aqueous and organic phases and reach equilibrium
- The role of distribution coefficients and how they influence extraction performance
- The differences between extraction, washing, back extraction, and back washing
- How to select suitable extraction solvents for different analytes and matrices
- Practical approaches to improving extraction efficiency using pH adjustment, salting-out techniques, temperature control, and derivatisation
- How extracts are separated, dried, concentrated, and prepared for analysis
- The use of manual and automated extraction systems including robotics and automated sample preparation platforms
What knowledge will I gain?
By the end of the course, you will:
- Understand the fundamental principles behind LLE and solvent extraction science
- Be able to explain how solutes transfer between immiscible liquid phases and reach equilibrium
- Understand how distribution coefficients influence extraction recovery and method effectiveness
- Know how solvent properties, polarity, miscibility, and extraction conditions affect analytical performance
- Be familiar with methods used to enhance extraction performance including pH adjustment, salting out, temperature control, and derivatisation
- Understand the principles of both traditional and modern LLE techniques
- Gain confidence in designing and optimising extraction methods for different analytes and matrices
- Understand the operation and application of automated extraction workflows.
- Be able to identify and troubleshoot common issues including emulsion formation, solvent selection challenges, particulate interference, and volatile analyte losses
- Gain an appreciation of how LLE is applied in environmental, industrial, pharmaceutical, food, and analytical testing laboratories
Is this course for me?
This RSC approved, for purposes of CPD, Hands-on LLE training is designed for anyone who wants a practical understanding of LLE as a sample preparation method.
- Laboratory analysts and technicians performing sample preparation and extraction procedures
- Scientists developing analytical methods involving GC, GC-MS, LC, or LC-MS.
- Laboratory managers overseeing sample preparation and analytical workflows
- Data analysts and report writers seeking a better understanding of how sample preparation influences analytical results
- Service engineers supporting sample preparation and analytical laboratory equipment
- Sales, marketing, and commercial professionals working with analytical instrumentation, automation systems, chemicals, or sample preparation products
- Researchers and scientists looking to strengthen their understanding of extraction science and laboratory best practice
If LLE touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.
Course combinations
Can’t attend the full course? No worries, combine days or modules to create training that works best for you. The more days you book the larger the discount.
- For 2 days, pay £1250
- For 3 days, pay £1825
- For 4 days, pay £2350
- For 5 days, pay £2850
Please note, discounts won’t apply when booking but will appear on your invoice.
