Hands-on Solid-Phase Extraction
- Duration: 1 day for live courses
- Experience level: Advanced
- Delivery methods: Face-to-face | Offsite training & consultancy | Onsite training & consultancy | Tailored training |
- Type of course: Universal
- Applicable to manufacturer(s): Agilent | Bruker | CTC analytics | GERSTEL | GL Sciences | Leco | PerkinElmer | Sciex | Scion | Shimadzu | SRI | Thermo | Varian | Waters |
- CPD Approved: Approved
- Scheduled course price: £650.00 + TAX per delegate
- Course discounts: RSC CAMS HEaTED Cambridge Network members receive a discount on this course
Your Hands-on approach to learning solid phase extraction
Module 2 of the Hands-on of Sample Preparation course.
Combine the practical theory of solid phase extraction (SPE) with laboratory-based exercises when attending this Hands-on training course approved by the Royal Society of Chemistry (RSC) for purposes of Continuing Professional Development (CPD). Apply the knowledge learned in each module through practical exercises involving sample preparation, sorbent selection, method development, optimisation, automation, and troubleshooting. Gain experience of SPE workflows, cartridges, sorbents, solvents, and analytical techniques used to isolate, clean up, and concentrate analytes from complex sample matrices. This course provides a practical introduction to one of the most widely used sample preparation techniques in analytical chemistry.
This Hands-on SPE course is designed for analysts, scientists, technicians, and laboratory professionals who would like to develop both a practical and theoretical understanding of solid phase extraction techniques. The course combines SPE theory, sample preparation, sorbent selection, optimisation, troubleshooting, and real-world applications with laboratory-based exercises that reinforces learning and builds confidence.
Why should I join?
On completion of this Hands-on SPE training, you will have both a strong theoretical understanding and practical experience of developing, performing, optimising, and troubleshooting SPE methods.
This Hands-on SPE course gives you:
- A clear understanding of the principles behind SPE and chromatographic extraction
- Practical experience of designing and performing SPE procedures
- How SPE can be used for sample clean-up, analyte enrichment, and solvent exchange
- Insight into sorbent selection and analyte-sorbent interactions
- Practical guidance on method optimisation including conditioning, equilibration, loading, washing, and elution
- Hands-on experience with silica-based, polymeric, ion-exchange, and mixed-mode SPE sorbents
- Exposure to modern SPE approaches including dispersive SPE, QuEChERS, MEPS, and automated SPE workflows
- Practical troubleshooting techniques for solving common SPE problems
What would I learn?
This course focuses on providing an in-depth understanding of SPE with practical Hands-on experience. You will learn:
- The principles of SPE and chromatographic sample preparation.
- How analytes interact with mobile and stationary phases during extraction.
- The role of retention mechanisms and partitioning in SPE performance.
- How to select suitable SPE sorbents for different analytes and sample matrices.
- The principles of reversed-phase, normal-phase, ion-exchange, mixed-mode, and polymeric SPE.
- Practical approaches to method development and optimisation
- How conditioning, equilibration, loading, washing, and elution influence extraction efficiency and recovery
- The influence of pH, solvent strength, polarity, and analyte chemistry on SPE performance
- How to assess analyte recovery, matrix effects, and method robustness
- The use of manual and automated SPE systems including robotic workflows and online SPE platforms
- Modern sample preparation approaches including dispersive SPE, QuEChERS, and micro-extraction by packed sorbents (MEPS)
What knowledge will I gain?
By the end of the course, you will:
- Understand the fundamental principles behind SPE and chromatographic extraction science
- Be able to explain how analytes are retained, separated, and eluted from SPE sorbents
- Understand how analyte properties, solvent systems, and sorbent chemistry influence extraction performance
- Know how SPE can be used to reduce matrix effects, remove contaminants, and improve analytical sensitivity
- Be familiar with silica-based, polymeric, ion-exchange, mixed-mode, and selective SPE sorbents
- Understand the principles of normal-phase, reversed-phase, and ion-exchange extraction strategies
- Gain confidence in designing and optimising SPE methods for different analytes and sample matrices
- Understand the operation and application of automated SPE workflows
- Be able to identify and troubleshoot common issues including poor recovery, analyte breakthrough, matrix interferences, poor retention, and inefficient elution
Is this course for me?
This RSC-approved, for purposes of CPD, Hands-on SPE course is designed for anyone who wants a practical understanding of SPE as a sample preparation technique.
- Laboratory analysts and technicians performing sample preparation and extraction procedures
- Scientists developing analytical methods involving GC, GC-MS, LC, or LC-MS
- Laboratory managers overseeing sample preparation and analytical workflows
- Data analysts and report writers seeking a better understanding of how sample preparation influences analytical results
- Service engineers supporting sample preparation and analytical laboratory equipment
- Sales, marketing, and commercial professionals working with analytical instrumentation, automation systems, consumables, or sample preparation products
- Researchers and scientists looking to strengthen their understanding of extraction science and laboratory best practice
If SPE touches your work in any way, this well-planned course delivered by experts in the field equips you to understand the science behind these techniques.
Course combinations
Can’t attend the full course? No worries, combine days or modules to create training that works best for you. The more days you book the larger the discount.
- For 2 days, pay £1250
- For 3 days, pay £1825
- For 4 days, pay £2350
- For 5 days, pay £2850
Please note, discounts won’t apply when booking but will appear on your invoice.
